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KMID : 1007520190280030857
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Food Science and Biotechnology
2019 Volume.28 No. 3 p.857 ~ p.864
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The protective effects of Gastrodia elata Blume extracts on middle cerebral artery occlusion in rats
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Seok Pu-Reum
Oh Su-Jin
Choi Jin-Woo
Lim Cho-Rong
Choi Jong-Ryeol
Kim Jung-Hoan
Shin Jae-Ho
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Abstract
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To investigate the effects of Gastrodia elata Blume (GEB) and 4-hydroxybenzyl alcohol (HBA) on brain damage, GEB or HBA was administered orally for 14 days before middle cerebral artery occlusion (MCAO). After 24 h reperfusion, the proportion of circling was significantly reduced in the GEB (79%) or HBA (69%) group compared to the MCAO group (100%) in the corner test, and the removal time in the adhesive removal test was significantly decreased in the GEB (117?±?21.0 s) and HBA (101?±?20.9 s) groups compared to the MCAO group (161?±?12.6 s). GEB treatment significantly reduced infarct volume compared to the MCAO group. In the GEB and HBA group, necrosis of nerve cells in hippocampus and cortex, expressions of TNF-α and TUNEL positive cells were significantly reduced compared to the MCAO group. These results suggest that GEB and HBA prevents brain damage by anti-inflammatory and anti-apoptotic effects.
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KEYWORD
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Middle cerebral artery occlusion, Brain ischemia, Gastrodia elata Blume, 4-Hydroxybenzyl alcohol, Rat
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